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Estrace is utilized for treating problems due to menopause (eg, hot flashes; genital itchiness, burning, or dry skin), dealing with vulval or vaginal atrophy, as well as stopping osteoporosis (fragile bones). Estrace is used for treating problems because of menopause (eg, hot flashes; genital irritation, burning, or dryness), dealing with vulval or vaginal atrophy, as well as preventing weakening of bones (fragile bones). Take with food to lower belly irritability if belly distressed takes place.